Bim appears to play no role (Figure 5b), in contrast to the situation observed for Eμ-myc lymphomas where Bim, Puma and Noxa were all involved in killing by DNA damage-inducing drugs.54 Although not as efficacious as daunorubicin, bortezomib also extended the life of AML-transplanted mice (Figure 6) and the in vitro data suggests this response is highly Noxa-dependent. This evidence concerns the gene BBC3 and acute myeloid leukemia.