Loss of Bim, Puma, Noxa, Bmf or combinations thereof, made no significant difference to the kinetics of morbidity (Figures 1b and c and Supplementary Figure S1a) or degree of splenomegaly (Figure 1d,Supplementary Figure S1b), although circulating leukocytes were significantly elevated in sick bim−/−/MLL-AF9 and bim−/−/MLL-ENL mice compared with their WT/MLL-AF9 and WT/MLL-ENL counterparts, principally due to a greater increase in myeloid cells (Mac1+Gr1+; see Supplementary Table S1). This evidence concerns the gene BMF and Splenomegaly.