Reduced caspase-9 activity and maintenance of mitochondrial membrane potential were observed in sepsis patients where neutrophil apoptosis is delayed.19 Moreover, it is noteworthy that caspase-9 activity was reduced in presence of caspase-8 inhibitor indicating caspase-8-dependent induction of mitochondrial death pathway and caspase-9 activation (Figure 3). Here, CASP8 is linked to Sepsis.