Similarly, we detected a HR of CHD, i.e. 1.62 (95%CI: 1.23–2.14), 1.43 (95%CI: 1.17–1.75), 2.17 (95%CI: 1.51–3.12) and 1.57 (95%CI: 1.27–1.94), respectively, for HMOX1 rs5995098, APOE rs429358, AGT rs699 and rs5046, as well as a decreasing trend. This evidence concerns the gene APOE and coronary artery disorder.