Patients with a more severe endotype of NP such as eosinophilic NP, or CRSwNP patients who had concomitant respiratory diseases such as bronchial asthma showed higher IL-10 expression levels in their blood or tissue samples, as opposed to patients who suffered a milder endotype of NP such as non-eosinophilc NP, or CRSwNP patients without any concomitant respiratory diseases [13–17,21,22,35,45–49]. This evidence concerns the gene IL10 and respiratory system disorder.