We also extend the prior literature to report that the benefits of weight loss on testosterone SHBG and overall sexual function for all participants and erectile function for those with baseline erectile dysfuncton was independent of the potential moderating effect of cardiometabolic and psychological status including consideration of the effect of surrogate markers of insulin resistance, dyslipidaemia, inflammation, glycaemia and depressed mood while the change in erectile function were ameliorated on adjustment for changes in anthropometry. This evidence concerns the gene SHBG and Insulin resistance.