The autoantibody-binding target Ku is known to be involved in double-stranded DNA repair.[4–8] Schild-Poulter et al[23] found that anti-Ku autoantibodies were often associated with autoantibodies directed against other DNA repair proteins, and suggested that B-cell responses to latent or persistent DNA damage may be involved at the onset or during the development of autoimmunity in certain systemic autoimmune rheumatic diseases. The gene discussed is XRCC6P5; the disease is Autoimmunity.