This literature-based meta-analysis involving 1141 previously treated patients with advanced NSCLC who showed disease progression during or after first-line chemotherapy showed encouraging results; the findings indicated that anti-PD-1/PD-L1 antibody therapy could significantly improve the ORR and OS compared with single-agent docetaxel chemotherapy alone, without evidence of statistical heterogeneity. Here, CD274 is linked to non-small cell lung carcinoma.