During the process of occurrence and development of tumor, the gene expression is interfered and influenced with each other, so that is complicated and varied in DNA, RNA, and protein expression level, but SELENBP1 expression has not been regulated by other factors, which suggested its expression located in upstream of tumor gene regulation and plays a leading role in the initiation and development of the disease, so it is suggested that SELENBP1 is involved in cancer prevention and treatment of trace element selenium. Here, SELENBP1 is linked to cancer.