SELENBP1 and laryngotracheoesophageal cleft: As mentioned in previous literature, different HNSCCs have obvious distinguish in the pathological type, the malignant degree and prognosis, the expression of SELENBP1 also has difference in our research, the expression of SELENBP1 in LC is relatively high, corresponding with the lower malignant and better prognosis (Fig. 4).