In our first study, analysis of GEO dataset showed that expression of SELENBP1 gene in general cancer and HNSCC has significant downregulation different from normal tissues, according to some literature reports.[22,23] SELENBP1 expression in the beginning and advance stage of tumor has obvious difference relative to tumor margin, but between the 2 has no difference. Here, SELENBP1 is linked to head and neck squamous cell carcinoma.