RARRES2 and obesity due to melanocortin 4 receptor deficiency: Chemerin, which is released by adipose tissue, is strongly correlated with obesity.[10] The relationship between serum concentrations of chemerin and BMD has not been extensively investigated despite the close association of obesity and BMD.[1] In the current study, we found that serum chemerin level was positively associated with TNF-α and negatively associated with BMD of the lumbar spine.