Chemerin may be at the crossroads of inflammation and obesity because of its dual role in immune system and metabolism.[14] Serum chemerin concentrations are increased in overweight and obese subjects.[15–17] Moreover, chemerin levels are positively correlated with different obesity measures, such as BMI, and well-established markers of inflammation.[10,18,19] In vitro studies have shown that chemerin regulates adipocyte development and metabolic function.[20,21]. The gene discussed is RARRES2; the disease is obesity due to melanocortin 4 receptor deficiency.