Chemerin is widely expressed by various cell types such asadipocytes, osteoblasts, HSC, mesenchymal stem cells (MSCs), and macrophages.[21–24] The multipotent role of MSCs has been proposed as a key mediator in the pathogenesis of osteoporosis, and the reduction in bone mass is partly believed to result from common precursor cells that become fat instead of bone.[25] Chemerin is a negative regulator during bone formation.[3] Chemerin stimulates adipocyte differentiation of BMSCs by activation of CMKLR1. This evidence concerns the gene RARRES2 and osteoporosis.