The Snail and Twist transcription factors are well characterized regulators of mesenchymal identity and also play a role in EndoMT during embryonic development as well as in pathologic fibrotic conditions like cancer [56,57] Most intriguingly, the results also demonstrate that ET-1 was able to induce a potent increase in the expression of TGF-β1 and TGF-β2 (Fig 5) and of the three TGF-β receptors (Fig 6). This evidence concerns the gene EDN1 and cancer.