TAZ is a key mediator of mechanotransduction, also implicated in human tumorigenesis: TAZ transducer activities are required to sustain self-renewal and tumor-initiation capacities [29], cell proliferation and EMT in breast cancer stem cells [28, 68] and to regulate mesenchymal differentiation in malignant gliomas [50]. This evidence concerns the gene WWTR1 and malignant glioma.