However, the most dramatic increase was in the number of nonclassical monocytes (NCMs, defined as CD11b+ F4/80+ Ly6Clo SSClo Ly6G-; Fig 3C and [47]), which increased by thirty-fold after 100 days of infection and sixty-fold by day 200 (Fig 3B and 3D). The gene discussed is ITGAM; the disease is infection.