As is shown in Table 1, the methylation of CCND2 was observed in 29/102 (28%) of RCC tumors, but only 2/23 (8.7%) in adjacent non-malignant tissues (Table 1), which suggested that CCND2 methylation was more likely to occur in tumor tissues, as is shown in Fig 4A. This evidence concerns the gene CCND2 and neoplasm.