Hypermethylation at CpG-rich region with no mRNA expression of CCND2 was detected in 5/6 RCC cell lines (786-O, A498, CAKI-1, 769P, OSRC), but was not detected in CAKI-2 and HK-2 with CCND2 mRNA expression (Fig 2B). This evidence concerns the gene CCND2 and renal cell adenocarcinoma.