CYP21A2 and congenital adrenal hyperplasia: When testing two GF strains derived from congenital adrenal hyperplasia individuals carrying CYP21A2 mutations and having a 46,XX karyotype, their APOD response to DHT was comparable with that of male controls, confirming that the AR can be activated by DHT in GF independently of the chromosomal sex (Figure 2, A and B).