In line with these previous findings, the current study revealed the abundance and up-regulation of LPA6 expression, the correlation of LPA6 expression with microvascular invasion in HCC, and high levels of LPA6 expression in HCC with high serum ATX levels as risk factors for recurrence, which suggested the roles of LPA6 in the malignant potential of HCC. Here, ENPP2 is linked to hepatocellular carcinoma.