Recent studies suggested that it was not visceral fat or total body fat but liver fat content that was the major determinant of serum SHBG levels in human subjects [36, 37] and SHBG might be one of the candidates linking nonalcoholic fatty liver disease (NAFLD) which was involved in the pathogenesis of diabetes [38]. The gene discussed is SHBG; the disease is metabolic dysfunction-associated steatotic liver disease.