HIF1A and renal cell carcinoma: In the literature review, Lidgren et al. (13) tracked HIF-1α positivity in RCC samples with low degree, early stage, and high survival rates and accepted HIF-1α positivity as an indicator of a good prognosis; while Klatte et al. (23) found HIF-1α positivity in RCC with renal cells and found no relationship between stage, FNG, and HIF-1α staining.