BRCA1 and neoplasm: During normal cellular activities, BRCA1 interacts with its binding partner, BARD1 (BRCA1-associated ring domain protein), to ensure genomic stability and cell survival.3 In this context, BRCA1 functions as a tumor suppressor by safeguarding genetic material.4–6 A critical opportunity to monitor for errors in DNA, and to correct them, occurs during RNA synthesis.