Recent evidence from prospective multi-ethnic cohort studies have identified a strong association between NAFLD and genetic mutation in several genes including lipolytic enzymes, patatin like phospholipase (PNPLA-3) domain, neurocan gene NCAN and glucokinase regulatory protein gene GCKR in non-Hispanic whites and subjects of European descents respectively [28, 29]. The gene discussed is GCKR; the disease is metabolic dysfunction-associated steatotic liver disease.