The importance of MBL in RA physiopathology is reinforced by the observation of a nucleotide polymorphism (SNP) at MBL gene associated RA susceptibility (Ip et al., 2000; Jacobsen et al., 2001), and with HSV infection reccurences, possibly due to impaired recognition of the viruses (Seppanen et al., 2009). Here, MBL2 is linked to rheumatoid arthritis.