In early RA, low MBL levels were revealed, which are associated with a higher risk of developing early erosive RA and higher levels of IgM RF and CRP (Jacobsen et al., 2001; Saevarsdottir et al., 2001), and later, the MBL levels are increased (Saevarsdottir et al., 2007). The gene discussed is CD40LG; the disease is rheumatoid arthritis.