Additional immunosuppression via cyclosporine A administration, the loss of T cells or interferon gamma signaling increases the prevalence of lymphoproliferative disease, mirroring the development of gHV-associated malignancies in immunosuppressed humans (Sunil-Chandra et al., 1994; Tarakanova et al., 2005, 2008; Lee et al., 2009). The gene discussed is GH2; the disease is cancer.