NPY and temporal lobe epilepsy: For example, studies in temporal lobe epilepsy, the most common type in adults, have revealed deficits in hippocampal pyramidal neuron distal dendritic domain-targeting interneurons, including interneuron subpopulations expressing somatostatin (SST; Buckmaster and Jongen-Rêlo, 1999; Cossart et al., 2001; Kobayashi and Buckmaster, 2003), neuropeptide Y (NPY; Mathern et al., 1995; Sundstrom et al., 2001), and calbindin (CB; Wittner et al., 2002).