Glycogen synthase kinase 3beta (GSK3β), a downstream molecule of Akt or PKA, is involved in many physiological and pathological processes, such as synaptic plasticity (Ochs et al., 2015), tau pathology of Alzheimer's disease (Hernandez et al., 2013) and ethanol-induced neuronal excitotoxicity (French and Heberlein, 2009; Luo, 2009; Zeng et al., 2012; Shah et al., 2015). Here, AKT1 is linked to early-onset autosomal dominant Alzheimer disease.