ERBB3 and cancer: DJ-1 overexpressing MCF-7 xenograft tumors had higher HER3 levels without HER3mAb treatment (Figure 6F), but HER3Mab treatment reduced the total HER3 levels, pHER3 levels, and pAKT in tumors from both DJ-1 overexpressing and pcDNA control MCF-7 cancer cells (Figure 6F).