HER3Mab treatment significantly reduced the sphere sizes in both the pcDNA control and DJ-1 overexpressing T47-D and MCF-7 cells (p<0.05), but the effect was more profound in DJ-1 overexpressing cells than in control cancer cells, as indicated by 75% vs 67% reduction in sphere diameters in T47-D cells and 83% vs 74% reduction in sphere diameters of MCF-7 cells (Figure 5C). This evidence concerns the gene PARK7 and cancer.