Although TRAIL selectively induces cancer cell death, the down-regulation of pro-apoptotic proteins and death receptors and up-regulation of anti-apoptotic proteins such as c-FLIP, Bcl-2, Bcl-xL and inhibitor of apoptosis proteins (IAPs) lead to resistance to TRAIL-induced apoptosis [10–14]. This evidence concerns the gene TNFSF10 and cancer.