SinceMEK/ERK signaling activation has been deemedfundamental for intestinal tumor development in ApcMin/+ mice [31], immunoblot analyses were performed to elucidate whether changes in ERK phosphorylation status can be observed in colon epithelial samples and polyps after expression of the activated SHP-2E76K mutant. The gene discussed is MAPK1; the disease is intestinal neoplasm.