Melanoma cell lines were exposed to 100μM propranolol for 24h, Bax was significantly increased in A375 (Figure 3A, Aa, P <0.001), P-3 (Figure 3A, Ab, P <0.01) and P-6 (Figure 3A, Ac, P <0.01) cell lines, while Bcl-2 was decreased in the three melanoma cell lines (Figure 3B, Ba-Bc, P <0.01). This evidence concerns the gene BCL2 and melanoma.