MTOR and Miyoshi myopathy: Four drugs blocked proliferation in all five MM cell lines tested: the PLK-1 inhibitor BI2536 (IC50 0.01-0.05 μM), the pan-BCL-2 antagonist obatoclax (IC50 0.1-0.5 μM), the HSP90 inhibitor 17AAG (IC50 0.01-1 μM), and the PI3 kinase/mTOR inhibitor BEZ235 (IC50 0.01-1 μM) (Table 1).