Overexpression of a control vector or a cDNA encompassing CREBH wild type (CREBH WT) in McA-RH7777 (McA) cells, a rat hepatoma cell line, was unable to stimulate mRNA transcription of SREBP-1c and SREBP-2 (Supplementary Fig. S2A), indicating that CREBH is unlikely to regulate SREBPs at the transcriptional level. Here, SREBF2 is linked to hepatocellular carcinoma.