As shown in the figure, this subnetwork contains 5 genes associated to BD (ADCY2, CACNB2, ANK3, CACNA1C, and PIK3C2A), 6 genes associated to AD (NOS3, APP, PTK2B, PSEN1, GRIN3B, and PSEN2), and 60 aging genes. The gene discussed is APP; the disease is Alzheimer disease.