In this study, we demonstrated that the MAPKp44/42/ERK1/2 pathway can be activated by genistein in human uterine leiomyoma cells and lead not only to elevated levels of phospho-MAPKp44/42 but also to increased levels of downstream nucleosome effectors phosphorylated MSK1 and H3S10ph, and their colocalization. The gene discussed is RPS6KA5; the disease is Uterine leiomyoma.