In response to smooth muscle injury, EGR1 may activate matrix remodeling genes and profibrotic genes such as TGF-β, PDGF, and Collagen 1 genes [29, 30], which have all been suggested as etiological factors involved in the pathogenesis of human uterine leiomyomas. This evidence concerns the gene EGR1 and uterine corpus leiomyoma.