EZH2 and cancer: 2010). This implies that some of the mechanisms used in cancer may also be involved in IPF. The objectives of this study are to determine the EZH2 expression in human patients with IPF and in bleomycin‐induced murine pulmonary fibrosis, effects of EZH2 inhibition on the differentiation of fibroblasts to myofibroblasts, how EZH2 affects the TGF‐β signaling pathway, and the effects of EZH2 inhibition on pulmonary fibrosis in an in vivo mouse model.