Given the Wnt11 deficiency dependent changes in the kidney tubular system we also examined possible changes in the genes encoding the “core” PCP pathway and certain other genes (e.g. TCS2, PDK1 and HNF1b) involved in cystic kidney diseases by qRT-PCR using E16.5 and NB kidneys. This evidence concerns the gene HNF1B and cystic kidney disease.