EPOR and plasma cell myeloma: For newly diagnosed myeloma patients in the TT2 (n = 278) and TT3A (n = 245) trials, ROC-high EPOR expression levels were significantly associated with longer overall survival (P = 0.004, hazard ratio = 0.17; P = 0.011, hazard ratio = 0.12, respectively) (Fig. 4a, b).