ERBB2 and gastric cancer: However, when lapatinib, a small-molecule tyrosine kinase inhibitor (TKI) targeting HER2 and epithelial growth factor receptor (EGFR), was combined with either first- (LOGiC) or second-line (TyTan) chemotherapies, no statistically significant improvement in OS was observed in gastric cancer patients with HER2 amplification defined by fluorescence in situ hybridization (FISH) [11].