A lot of tumor suppressors and oncoproteins, including the PI3K/AKT/mTOR signaling pathway, Myc, p53, and hypoxia-inducible factor-1 (HIF-1), have been reported to be involved in the regulation of the Warburg effect that favors tumor cell growth, proliferation, and stress resistance [57]. This evidence concerns the gene AKT1 and neoplasm.