PLCB3 and acute lymphoblastic leukemia: Triple staining for CD3ɛ, Gαq/11 and p-PLCβ3 displayed a high degree of co-localization, consistent with the notion that these proteins are assembled into complexes upon anti-CD3 stimulation in Jurkat (Fig. 2i), Molt-4 (Fig. 2j) and primary T-ALL cells (Fig. 2k).