PPARGC1A and autism: In particular, the loss of Purkinje cells is characteristic of diseases and disease models that include essential tremors42, Cockayne syndrome43, experimental autoimmune encephalomyelitis44, PGC-1a knock-out mice45, leaner mouse models46, neuronal nitric oxide synthase deficient mouse models47, paraneoplasmic cerebellar degeneration48, and a three-factor autism model36, 49.