SPARC and myeloid sarcoma: Altogether, its potential roles in modulating angiogenic and barrier parameters of vascular development and repair [19, 23, 35, 36], its expression and influence on neural regeneration after CNS injury [33, 34], and its influence on the profile and extent of immune infiltration [37, 38] make SPARC a molecule of particular interest in chronic neuroinflammatory pathologies such as MS.