INS and type 1 diabetes mellitus: Regardless of the mechanism(s) instigating the reduced insulin sensitivity in T1DM4, 6, 12, 13, 14, there is robust data demonstrating that insulin-resistant persons with T1DM are at a significantly greater risk of developing microvascular and macrovascular complications4, 15, 16, 17, 18, 19, 20, 21, 22.