These novel driver mutations hit histone proteins (HIST1H1D; HIST1HIC) involved in resistance to lenalidomide in multiple myeloma (IKZF3), nuclear RNA export factor 1 (NXF1) and proteins also mutated in acute myeloid leukemia and multiple myeloma (ASXL1; TRAF3) [59]. The gene discussed is IKZF3; the disease is plasma cell myeloma.