In this study, we reported that CaN inhibitors (CsA and FK506) inhibited proteinuria in PAN-induced nephrotic syndrome in rats by protecting against podocyte injury via mechanisms associated with reducing the foot-process effacement, reversing the disorganization of cytoskeleton and the loss of podocyte phenotype, and inhibiting the podocyte apoptosis in models of PAN-induced injury. The gene discussed is NUP214; the disease is polyarteritis nodosa.