DIO3OS and Familial prostate cancer: In prostate cancer, six lncRNA (LINC00341, RP11-291L15.2.1, DIO3OS, RP11-65F13.2.1, WDFY3-AS2 and RP11-629G13.1.1) cooperatively regulated TGFB which is critical for the development of tumor (Figure 7D).