To examine how miRNAs mediate these conserved ceRNA pairs in pan-cancers and to gain insight into the commonalities of various cancers, we focused on two ceRNA pairs: OIP5-AS1-BRCA1 and TUG1-TGFBR2, both of these two mRNAs are cancer driver genes and lncRNAs with highly degree in the subnetwork. This evidence concerns the gene PTGDR and cancer.