We observed, the parasitized splenic DCs from LdCen-/- infected young and aged mice at 4 days post-infection exhibited similar and significant up regulation of proinflammatory cytokine genes such as IL-12, IL-6, IFN-γ and TNF whereas down regulation of anti-inflammatory cytokine gene IL-10 compared to LdWT infected mice. The gene discussed is TNF; the disease is infection.