TGFB1 and hepatocellular carcinoma: Most notably, our team previously discovered that SHP-1 acts as a strong suppressor, preventing TGF-β1-induced EMT characteristics in vitro and inhibiting metastatic growth in vivo in hepatocellular carcinoma (HCC) by exerting tyrosine phosphatase activity that downregulates p-STAT3Tyr705 directly [14].