In RLDs, instead, most of cases were captured through non-insulin antidiabetic drugs utilization which cannot identify those patients at a earlier stage of the disease who are not on drug treatment (do diet only) and may also misclassify T2DM with other diseases for which the same drugs can sometimes be used (e.g. polycystic ovary syndrome).[4] Supposing that the validity of the latter case-finding algorithm was completely unknown, data reported in Table 3 can be used to obtain an approximation of its expected sensitivity and PPV. The gene discussed is INS; the disease is type 2 diabetes mellitus.