CD34 and Increased total leukocyte count: Regardless, a proportion of genuine ET patients in these studies had leukocytosis, significant increase in circulating CD34+ cells and enlarged spleens (the latter accounting for about 15–20%) [8–9,11] but still major findings included significant differences for leukocyte count, platelet count, serum LDH, circulating CD34 cell count, incidence of palpable splenomegaly, and frequency of grade 1 BM fibrosis–all variables being greater in early/prePMF than ET [9].