Firstly, it has unraveled a unique gene signature composed of 7 genes (MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8), which are capable of distinguishing genuine ET from prePMF with a high sensitivity (100%), specificity (89%) and balanced accuracy (94%) when using LDH at the time of diagnosis as the biochemical variable. Here, CRISP3 is linked to essential thrombocythemia.