CD34 and Splenomegaly: If strictly adhering to the histopathological description of genuine ET versus early prePMF, patients with genuine ET have no significant granulopoiesis in the bone marrow8 and accordingly should have no or no significant leukocytosis and no significant splenomegaly, when taking into account that splenic enlargement implies extramedullary hematopoiesis due to egress of CD34+ cells and progenitors from the bone marrow consequent to enhanced granulopoiesis with in vivo activation of granulocytes and ensuing release of neutrophil granule contents [50–51].