The causal relationship between PARP3 and TG2 to regulate the EMT master regulator Snail is grounded by the considerable functional similarities between these proteins : (i) they promote mesenchymal properties, cell migration, wound healing [39, 43, 44]; (ii) their expression is induced by genotoxic stress and they prime a drug resistance phenotype [29, 45, 46]; (iii) they confer cancer stem-like cell traits [18, 44]. The gene discussed is TGM2; the disease is cancer.