TGFB1 and Myocardial fibrosis: Another pro-fibrotic gene, β-catenin has been demonstrated to have crosstalk with TGF-β, [11, 15, 16] which is complex and context-dependent, [16] while our previous study demonstrated that fractalkine (FKN) plays an important role in the promotion of myocardial fibrosis and cardiac remodeling via up-regulating matrix metallopeptidase 9, procollagen I and III, and TGF-β.