Immunohistochemistry results clearly showed an increased expression of active β-catenin protein in AAV-FGF23-IR or MI mice than in AAV-NC-IR or MI mice (Figure 6A-6C), especially in the ischemic area of IR mice (Figure 6A and 6C) or border area of MI mice (Figure 6B and 6C). The gene discussed is FGF23; the disease is myocardial infarction.