NR5A2 and neoplasm: We further validated this finding in an independent set of paired histologically normal and tumor derived (PDAC) pancreatic tissue samples from 20 individuals by RT-qPCR for three NR5A2 isoforms and noted decreased expression in tumors for the majority of pairs (average fold change for paired samples was -78.5 for isoform 1, P = 2.0×10−3; -95.7 fold for isoform 2, P = 7.5×10−4; -31.3 fold for isoform 3, P = 1.5×10−3) (Figure 2).