At chr5p15.33, one of the four variants highly correlated with rs35226131 is a missense variant in the second exon of TERT (rs61748181: r2 = 1, D' = 1 in 1000G EUR) whereby the minor allele, associated with reduced risk of pancreatic cancer, changes amino acid 279 from alanine to threonine (A279T). This evidence concerns the gene TERT and familial pancreatic carcinoma.